ORAI1 Deficiency Impairs Activated T Cell Death and Enhances T Cell Survival

Death and Enhances T Cell Survival ORAI1 Deficiency Impairs Activated T Cell

ORAI1 is a pore subunit of Ca 2+ release-activated Ca 2+ channels that mediate TCR stimulation-induced Ca 2+ entry. A point mutation in ORAI1 (ORAI1 R91W) causes SCID in human patients that is recapitulated in Orai1 2/2 mice, emphasizing its important role in the immune cells. In this study, we have characterized a novel function of ORAI1 in T cell death. CD4 + T cells from Orai1 2/2 mice showe...

Viral FLIP Impairs Survival of Activated T

DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice

In humans, DOCK8 immunodeficiency syndrome is characterized by severe cutaneous viral infections. Thus, CD8 T cell function may be compromised in the absence of DOCK8. In this study, by analyzing mutant mice and humans, we demonstrate a critical, intrinsic role for DOCK8 in peripheral CD8 T cell survival and function. DOCK8 mutation selectively diminished the abundance of circulating naive CD8 ...

Producing Soluble Human Programmed Cell Death Protein-1: A Natural supporter for CD4+T cell Cytotoxicity and Tumor Cells Apoptosis

Background: Programmed cell death protein-1 (PD-1)/PD-L1 pathway is one of the immune checkpoint pathways involved in regulation of the immune responses and suppression of anti-tumor defense. PD-1/B7-H1-blocking antibodies improve immune responses such as cytotoxic activity of CD8+/CD4+T cells and also increase mortality of tumor cells; however their use is accompanied by adverse effects in pat...

Bcl-2 overexpression enhances tumor-specific T-cell survival.

Although immunotherapy based on the adoptive transfer of tumor-specific T lymphocytes has been shown to result in dramatic clinical responses in some patients, the relatively low levels of engraftment and persistence of the adoptively transferred cells may limit these responses in many patients. In an attempt to develop strategies for prolonging the survival of adoptively transferred T cells, w...